Diagnosing dementia

Dementia is a complex disease and as such, there is no single test for dementia.

To receive a diagnosis, doctors and specialists use a combination of assessments and tests to help people with dementia get the appropriate treatment and support.

If dementia is diagnosed in the early stages and treated correctly, a patient can still lead an active and fulfilled life. It is also important to speak to your GP if you think you may have dementia. Not all ‘dementia symptoms’ are dementia and the GP and other medical staff will run tests to rule out other conditions.

General practitioners, neurologists, geriatric psychiatrists, and other specialists employ the following tests below to diagnose dementia.

Mental Ability Tests

These include cognitive and neuropsychological exams that are given to people with symptoms of dementia to determine their mental capacities, such as memory, thinking, reflexes, and the ability to solve simple problems.

Although cognitive testing cannot diagnose dementia on its own, it can evaluate and give an overall sense if further evaluation is needed.

Blood and Laboratory Tests

Blood tests are usually required by a general practitioner to determine causes of symptoms that may be dementia or another condition.

These tests include checking of liver, kidney, and thyroid functions, vitamin B12 and folate levels, as well as possibilities of diabetes via checking of haemoglobin A1c.

Lumbar puncture

To investigate a suspected case of Alzheimer’s disease, medical professionals may request a lumbar puncture after other tests - such as a cognitive and blood tests - have taken place.

In Alzheimer’s disease there are abnormal levels of proteins called tau and amyloid in the brain. These proteins can be found in the cerebrospinal fluid and can be used to diagnose Alzheimer’s disease.

A lumbar puncture involves a special needle taking a sample of the cerebrospinal fluid from the lower back. This fluid flows around the spinal cord and the brain and levels of proteins in the cerebrospinal fluid can indicate Alzheimer’s disease.

Brain Scans/Imaging

These are used for diagnosing dementia after ruling out other possible diseases or complications. Brain scans are used as part of a wider assessment and can be used to check for other possible problems like a stroke or a brain tumour. MRI scans can help confirm a diagnosis of dementia, identify changes in the brain’s structure and function, as well as the type of disease causing it.

Psychiatric Evaluation

This helps doctors determine if depression or other mental health conditions are causing or contributing to a person’s symptoms. They include computerised tests and mood assessment to help doctors better understand cognitive difficulties experienced by a person.

Genetic Tests

Research shows certain genes may increase the risk of Alzheimer’s. A known gene defect can also cause some forms of dementia. Genetic tests can help doctors find out if a person is at risk for dementia. Talking with a genetic counsellor, family members and a doctor before and after a genetic test is important for your wellbeing.

Diagnosis at the Brain Bank

BRACE supports work at the South West Dementia Brain Bank, which stores and processes donated brain tissue. Donations are made by both people living with, and without dementia. Examining brain tissue post-mortem is, sadly, the most accurate way to diagnosis dementia. The work done at the Brain Bank supports better understanding of how and where dementia happens in the brain. The Brain Bank is a vital resource. You cannot get to clinical trial without using human brain tissue first. Without it, we wouldn’t have drugs for Alzheimer’s disease.